diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate

Base Information

Chemical Name:diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate
CAS No.:1430408-24-4
Molecular Formula:C₂₁H₂₁Cl₃FN₂O₃P
Molecular Weight:505.741
Hs Code.:

Synonyms:diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate

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Chemical Property of diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate

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Technology Process of diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate

There total 6 articles about diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1430408-22-2
diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

: 1430408-24-4
diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1016/j.ejmech.2012.12.056

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 1430408-24-4
diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium / ethanol / 18 h / 20 °C

2.1: ethanol / 16 h / Reflux

3.1: trimethylaluminum / hexane; dichloromethane / 1.42 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5.1: triethylamine / toluene / 0.08 h / 20 °C

5.2: 24 h / Reflux

5.3: 2 h / Reflux

6.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; trimethylaluminum; sodium; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene; 1.1: |Claisen Condensation;
DOI:10.1016/j.ejmech.2012.12.056

Reference yield:

: 1047670-24-5
N-methoxy-N-methyl-1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 1430408-24-4
diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]fluoromethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.1: triethylamine / toluene / 0.08 h / 20 °C

2.2: 24 h / Reflux

2.3: 2 h / Reflux

3.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2012.12.056