diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

Base Information

Chemical Name:diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate
CAS No.:1430408-22-2
Molecular Formula:C₂₁H₂₂Cl₃N₂O₄P
Molecular Weight:503.749
Hs Code.:

Synonyms:diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

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Chemical Property of diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

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Technology Process of diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

There total 5 articles about diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 913624-97-2
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 1430408-22-2
diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

Guidance literature:: phosphonic acid diethyl ester; With triethylamine; In toluene; at 20 ℃; for 0.0833333h;

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxaldehyde; In toluene; for 24h; Reflux;

With potassium carbonate; In toluene; for 2h; Reflux;
DOI:10.1016/j.ejmech.2012.12.056

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 1430408-22-2
diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / ethanol / 18 h / 20 °C

2.1: ethanol / 16 h / Reflux

3.1: trimethylaluminum / hexane; dichloromethane / 1.42 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5.1: triethylamine / toluene / 0.08 h / 20 °C

5.2: 24 h / Reflux

5.3: 2 h / Reflux

With lithium aluminium tetrahydride; trimethylaluminum; sodium; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene; 1.1: |Claisen Condensation;
DOI:10.1016/j.ejmech.2012.12.056

Reference yield:

: 1047670-24-5
N-methoxy-N-methyl-1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 1430408-22-2
diethyl [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]hydroxymethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.1: triethylamine / toluene / 0.08 h / 20 °C

2.2: 24 h / Reflux

2.3: 2 h / Reflux

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/j.ejmech.2012.12.056