3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

Base Information

Chemical Name:3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester
CAS No.:1393176-43-6
Molecular Formula:C₂₄H₂₁NO₄S
Molecular Weight:419.501
Hs Code.:

Synonyms:3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

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Chemical Property of 3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

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Technology Process of 3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

There total 1 articles about 3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 37129-23-0
ethyl 3-phenyl-1H-indole-2-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 1393176-43-6
3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: ethyl 3-phenyl-1H-indole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 10 ℃; Inert atmosphere;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

With hydrogenchloride; In water; N,N-dimethyl-formamide; mineral oil;

Reference yield: 85.0%

: 1393176-43-6
3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

: 1238252-70-4
(3-phenyl-1-tosyl-1H-indol-2-yl)methanol

Guidance literature:: 3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester; With diisobutylaluminium hydride; In toluene; at -78 - -10 ℃; for 0.75h; Inert atmosphere;

With water; In toluene; at -78 - 20 ℃;

With hydrogenchloride; In water; ethyl acetate; toluene;

Reference yield:

: 1393176-43-6
3-phenyl-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

: 1393176-46-9
1-[3-phenyl-1-(toluene-4-sulfonyl)-1H-indol-2-yl]ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / toluene / 0.75 h / -78 - -10 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C

2.2: -78 - 20 °C

3.1: diethyl ether; tetrahydrofuran / -78 - 0 °C / Inert atmosphere

4.1: triphenylphosphine; diphenylphosphoranyl azide; di-isopropyl azodicarboxylate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 h / 20 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; ethyl acetate; toluene;