Technology Process of 1-[3-phenyl-1-(toluene-4-sulfonyl)-1H-indol-2-yl]ethylamine
There total 7 articles about 1-[3-phenyl-1-(toluene-4-sulfonyl)-1H-indol-2-yl]ethylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethyl acetate;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 10 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: diisobutylaluminium hydride / toluene / 0.75 h / -78 - -10 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
3.2: -78 - 20 °C
4.1: diethyl ether; tetrahydrofuran / -78 - 0 °C / Inert atmosphere
5.1: triphenylphosphine; diphenylphosphoranyl azide; di-isopropyl azodicarboxylate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 h / 20 °C
With
oxalyl dichloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; hydrogen; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 10 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: diisobutylaluminium hydride / toluene / 0.75 h / -78 - -10 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
3.2: -78 - 20 °C
4.1: diethyl ether; tetrahydrofuran / -78 - 0 °C / Inert atmosphere
5.1: triphenylphosphine; diphenylphosphoranyl azide; di-isopropyl azodicarboxylate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 h / 20 °C
With
oxalyl dichloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; hydrogen; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
