(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

Base Information

Chemical Name:(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester
CAS No.:869015-29-2
Molecular Formula:C₃₉H₄₂N₂O₄
Molecular Weight:602.773
Hs Code.:

Synonyms:(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

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Chemical Property of (4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

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Technology Process of (4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

There total 8 articles about (4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 7223-42-9
1-(prop-2-yn-1-yl)pyrrolidine

: 869015-14-5
(4-[3,3-bis-(4-iodophenyl)allyloxy]-2-methylphenoxy)acetic acid methyl ester

: 869015-29-2
(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

Guidance literature:: With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 50 ℃; for 3h; Inert atmosphere;

Reference yield:

: 5630-56-8
4,4'-diiodobenzophenone

: 869015-29-2
(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h

1.2: 0.5 h / Reflux

1.3: 0.5 h

2.1: di-isopropyl azodicarboxylate; tributylphosphine / benzene / 18 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

With tributylphosphine; di-isopropyl azodicarboxylate; magnesium; ethylene dibromide; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; benzene; 2.1: Mitsunobu reaction;

Reference yield:

: 166953-80-6
(4-acetyl-2-methylphenoxy)acetic acid methyl ester

: 869015-29-2
(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 20 °C

2: sodium methylate; methanol / 24 h

3: di-isopropyl azodicarboxylate; tributylphosphine / benzene / 18 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

With methanol; tributylphosphine; di-isopropyl azodicarboxylate; sodium methylate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; benzene; 3: Mitsunobu reaction;