(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid

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Chemical Name:(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid
CAS No.:869014-75-5
Molecular Formula:C₃₈H₄₀N₂O₄
Molecular Weight:588.747
Hs Code.:

Synonyms:(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid

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Chemical Property of (4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid

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Technology Process of (4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid

There total 9 articles about (4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 869015-29-2
(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester

: 869014-75-5
(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid

Guidance literature:: (4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid methyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; for 1.5h; Inert atmosphere; Cooling with ice-water;

With acetic acid; In tetrahydrofuran; methanol; water;

Reference yield:

: 5630-56-8
4,4'-diiodobenzophenone

: 869014-75-5
(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h

1.2: 0.5 h / Reflux

1.3: 0.5 h

2.1: di-isopropyl azodicarboxylate; tributylphosphine / benzene / 18 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / Inert atmosphere; Cooling with ice-water

With lithium hydroxide monohydrate; tributylphosphine; di-isopropyl azodicarboxylate; water; magnesium; ethylene dibromide; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; benzene; 2.1: Mitsunobu reaction;

Reference yield:

: 166953-80-6
(4-acetyl-2-methylphenoxy)acetic acid methyl ester

: 869014-75-5
(4-{3,3-bis-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)phenyl]allyloxy}-2-methylphenoxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 20 °C

2: sodium methylate; methanol / 24 h

3: di-isopropyl azodicarboxylate; tributylphosphine / benzene / 18 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

5: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / Inert atmosphere; Cooling with ice-water

With methanol; lithium hydroxide monohydrate; tributylphosphine; di-isopropyl azodicarboxylate; water; sodium methylate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; benzene; 3: Mitsunobu reaction;