Drocode

Base Information

• Chemical Name: Drocode
• CAS No.: 125-28-0
• Molecular Formula: C18H23 N O3
• Molecular Weight: 301.386
• Hs Code.: DERIVATION
• NSC Number: 231319
• DSSTox Substance ID: DTXSID80859235
• ChEMBL ID: CHEMBL4765015
• Mol file: 125-28-0.mol

Synonyms:Contugesic;DF 118;DHC Continus;DHC Mundipharma;Dicodin;dihydrocodeine;dihydrocodeine acetate, (5alpha,6alpha)-isomer;dihydrocodeine bitartrate;dihydrocodeine hydrochloride, (5alpha,6alpha)-isomer;dihydrocodeine phosphate (1:1), (5alpha,6alpha)-isomer;dihydrocodeine tartrate (1:1), (5alpha,6alpha)-(R-(R*,R*))-isomer;dihydrocodeine tartrate (1:1), (5alpha,6beta)-(R-(R*,R*))-isomer;dihydrocodeine, (5alpha,6alpha,14alpha)-isomer;dihydrocodeine, (5alpha,6beta)-isomer;dihydrocodeine, (5alpha,6beta,14alpha)-isomer;dihydrocodeine, thiocyanate salt (5alpha,6alpha)-isomer;Paracodin;Paracodina;paramol 118;Rikodeine;Tiamon;Tosidrin

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Drocode

Chemical Property:

• Appearance/Colour: white crystalline needles
• Vapor Pressure: 2.48E-09mmHg at 25°C
• Melting Point: 112-113°
• Refractive Index: 1.5740 (estimate)
• Boiling Point: 462°Cat760mmHg
• Flash Point: 233.2°C
• PSA: 59.00000
• Density: 1.31g/cm³
• LogP: 2.41060
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 301.16779360
• Heavy Atom Count: 22
• Complexity: 471

Purity/Quality:

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(CC4)O
• Therapeutic Function: Antitussive, Narcotic analgesic

Technology Process of Drocode

There total 94 articles about Drocode which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

codeine phosphate (52-28-8) → (-)-Dihydrothebainon (847-86-9) + dihydrocodeine (125-28-0)

Guidance literature:

With sodium hydroxide; hydrogen; platinum; 5% platinum on charcoal; In water; at 25 - 30 ℃; under 517.162 - 2585.81 Torr; pH=7.5;

Reference yield: 99.3%

codeine (76-57-3) → dihydrocodeine (125-28-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h; under 1913.45 Torr;

DOI:10.1080/00397910008086930

Reference yield: 98.2%

codeine phosphate (52-28-8) → (-)-Dihydrothebainon (847-86-9) + dihydrocodeine (125-28-0) + Hydrocodone (125-29-1)

Guidance literature:

With hydrogen; platinum; 5% platinum on charcoal; In water; at 25 - 30 ℃; under 517.162 - 2585.81 Torr; pH=4.2;

upstream raw materials:

Hydrocodone

codeine

dimethyl sulfate

codeine phosphate

Downstream raw materials:

Nordihydrocodeine

dihydrocodeine-6-O-acetate

4,5-epoxy-3-methoxy-17-methyl-(5α,6α)-morphinane-6-olbenzoate

Hydrocodone

Refernces

• 1、 Rapoport. "-". . p. 714,720. Retrieved 1948.
• 2、 Musazzi, Umberto M.,Matera, Carlo,Dallanoce, Clelia,Vacondio, Federica,De Amici, Marco,Vistoli, Giulio,Cilurzo, Francesco,Minghetti, Paola. "On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships". . p. 177 - 185. Retrieved 2015.
• 3、 Erbing, Elis,Vázquez-Romero, Ana,Bermejo Gómez, Antonio,Platero-Prats, Ana E.,Carson, Fabian,Zou, Xiaodong,Tolstoy, P?ivi,Martín-Matute, Belén. "General, Simple, and Chemoselective Catalysts for the Isomerization of Allylic Alcohols: The Importance of the Halide Ligand". supporting information. p. 15659 - 15663. Retrieved 2016/10/25.