[4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

Base Information

Chemical Name:[4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester
CAS No.:851227-20-8
Molecular Formula:C₂₃H₃₀O₅
Molecular Weight:386.488
Hs Code.:

Synonyms:[4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

Suppliers and Price of [4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of [4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

There total 8 articles about [4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 96-32-2
bromoacetic acid methyl ester

: 328236-47-1
3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol

: 851227-20-8
[4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.joc.5b02665

Reference yield:

: 328236-46-0
3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)-O-triisopropylsilylphenol

: 851227-20-8
[4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

2: 78 percent / Cs₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0440093

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 851227-20-8
[4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / dichloromethane / 6 h / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C

3: magnesium / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

4: hydrogen; palladium on activated charcoal; acetic acid / ethanol / 6 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

6: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; bromine; caesium carbonate; magnesium; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.5b02665