{4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester

Base Information

• Chemical Name: {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester
• CAS No.: 446312-38-5
• Molecular Formula: C₃₁H₃₃NO₇
• Molecular Weight: 531.606

Synonyms:{4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester

Chemical Property of {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester

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Technology Process of {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester

There total 17 articles about {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(4-Nitrophenyl)acetylene (937-31-5) + [4-(3-iodo-5-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester (446312-35-2) → {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester (446312-38-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 40h; Inert atmosphere;

DOI:10.1021/acs.joc.5b02665

Reference yield: 76.0%

p-nitrobenzene iodide (636-98-6) + methyl (4-{3-isopropyl-4-(methoxymethoxy)-5-[(trimethylsilyl)ethynyl]benzyl}-3,5-dimethylphenoxy)acetate (1172583-79-7) → {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester (446312-38-5)

Guidance literature:

With tetrabutyl ammonium fluoride; palladium diacetate; In tetrahydrofuran; at 20 - 65 ℃; for 1.33333h; Inert atmosphere;

DOI:10.1055/s-0028-1088041

Reference yield: 61.0%

{4-[3-(4-aminophenylethynyl)-5-isopropyl-4-methoxymethoxybenzyl]-3,5-dimethylphenoxy}acetic acid methyl ester (446312-37-4) → {4-[3-isopropyl-4-methoxymethoxy-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester (446312-38-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 - 20 ℃; for 3h;

DOI:10.1021/jm0201013

upstream raw materials:

{4-[3-(4-aminophenylethynyl)-5-isopropyl-4-methoxymethoxybenzyl]-3,5-dimethylphenoxy}acetic acid methyl ester

4-Ethynylaniline

3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)-O-triisopropylsilylphenol

4-(3-iodo-5-isopropyl-4-methoxymethoxy-benzyl)-3,5-dimethyl-phenol

Downstream raw materials:

2-(4-(3-isopropyl-4-(methoxymethoxy)-5-((4-nitrophenyl)ethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid

{4-[4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester

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