ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

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Chemical Name:ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate
CAS No.:866640-89-3
Molecular Formula:C₂₈H₃₆N₄O₅
Molecular Weight:508.618
Hs Code.:

Synonyms:ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

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Chemical Property of ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

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Technology Process of ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

There total 6 articles about ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866640-88-2
2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

: 866640-89-3
ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

Guidance literature:: 2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 14h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 639784-17-1
ethyl 2-(4-formyl-2,6-dimethylphenoxy)-2-methylpropanoate

: 866640-89-3
ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: magnesium sulfate / tetrahydrofuran / 4 h / Reflux

2: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 24 h / Reflux

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 14 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

6: trifluoroacetic acid / dichloromethane / 14 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; magnesium sulfate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513

Reference yield:

: C₂₁H₃₁NO₅

: 866640-89-3
ethyl 2-[4-({(2-hydrazinyl-2-oxoethyl)[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 24 h / Reflux

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 14 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

5: trifluoroacetic acid / dichloromethane / 14 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513