2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

Base Information

Chemical Name:2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester
CAS No.:866640-88-2
Molecular Formula:C₃₃H₄₄N₄O₇
Molecular Weight:608.735
Hs Code.:

2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

Synonyms:2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

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Chemical Property of 2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

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Technology Process of 2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

There total 6 articles about 2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866718-44-7
2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine

: 870-46-2
t-butoxycarbonylhydrazine

: 866640-88-2
2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine hydrochloride

: 870-46-2
t-butoxycarbonylhydrazine

: 866640-88-2
2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 639784-17-1
ethyl 2-(4-formyl-2,6-dimethylphenoxy)-2-methylpropanoate

: 866640-88-2
2-[4-[[[2-(N'-tert-butoxycarbonylhydrazino)-2-oxoethyl]-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: magnesium sulfate / tetrahydrofuran / 4 h / Reflux

2: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 24 h / Reflux

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 14 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; sodium tetrahydroborate; magnesium sulfate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513