ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Base Information

Chemical Name:ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate
CAS No.:1088714-05-9
Molecular Formula:C₁₇H₁₆BrFN₂O₃
Molecular Weight:395.228
Hs Code.:

Synonyms:ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

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Chemical Property of ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

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Technology Process of ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

There total 4 articles about ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1023742-62-2
ethyl 3-((4-bromo-2-fluorophenyl)amino)-3-iminopropanoate

: 10324-65-9
3-bromo-2-hydroxy-cyclohex-2-en-1-one

: 1088714-05-9
ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 18h;

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 1088714-05-9
ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl acetate / Reflux

2.1: sodium hydrogencarbonate / tetrahydrofuran / Reflux

2.2: Reflux

With sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/j.bmcl.2012.02.026

Reference yield:

: 1088714-34-4
ethyl 3-((4-bromo-2-fluorophenyl)amino)-3-iminopropanoate hydrochloride

: 1088714-05-9
ethyl 2-(4-bromo-2-fluorophenylamino)-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / water

2: tetrahydrofuran / 18 h / 60 °C

With sodium carbonate; In tetrahydrofuran; water;