tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate
CAS No.:1566544-10-2
Molecular Formula:C₃₂H₄₀N₆O₃
Molecular Weight:556.708
Hs Code.:

Synonyms:tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 885693-48-1
5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester

: 1566544-05-5
1-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl) cyclopropanecarboxamide

: 1566544-10-2
tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 120 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1566544-04-4
1-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl) cyclopropanecarboxamide

: 1566544-10-2
tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 110 h / 20 °C

2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

With platinum(IV) oxide; hydrogen; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 885693-47-0
tert-butyl 5-nitro-5’,6’-dihydro-[2,4‘-bipyridine]-1‘(2’H)-carboxylate

: 1566544-10-2
tert-butyl 4-(5-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide;