trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester

Base Information

Chemical Name:trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester
CAS No.:951656-22-7
Molecular Formula:C₂₃H₂₂O₅
Molecular Weight:378.425
Hs Code.:

Synonyms:trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester

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Chemical Property of trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester

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Technology Process of trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester

There total 3 articles about trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 951656-19-2
2-(3-methoxybenzoyl)benzofuran-5-carbaldehyde

: 35000-37-4
(tert-butyloxycarbonylmethyl)triphenylphosphonium chloride

: 951656-22-7
trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm0703136

Reference yield:

: 3328-70-9
5-formyl-2-hydroxybenzaldehyde

: 951656-22-7
trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / K₂CO₃ / acetonitrile / Heating

2: 90 percent / aq. NaOH; NEt₃ / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; potassium carbonate; triethylamine; In dichloromethane; acetonitrile; 2: Wittig olefination;
DOI:10.1021/jm0703136

Reference yield:

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 951656-22-7
trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / K₂CO₃ / acetonitrile / Heating

2: 90 percent / aq. NaOH; NEt₃ / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; potassium carbonate; triethylamine; In dichloromethane; acetonitrile; 2: Wittig olefination;
DOI:10.1021/jm0703136