3328-70-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxyisophthalaldehyde is used as a key intermediate for the synthesis of various pharmaceuticals, leveraging its reactivity to form complex organic molecules that possess therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-HIPA is utilized as a starting material for the production of compounds that contribute to crop protection and enhancement of agricultural yields.
Used in Organic Compounds Synthesis:
4-Hydroxyisophthalaldehyde serves as a building block in the synthesis of diverse organic compounds, capitalizing on its ability to undergo a range of chemical reactions to create functionalized derivatives.
Used in Material Development:
4-HIPA is employed in the development of new materials, taking advantage of its unique chemical properties to engineer innovative substances with specialized applications.
Used in Catalysis:
As a component in catalytic processes, 4-Hydroxyisophthalaldehyde contributes to the efficiency and selectivity of chemical reactions, further expanding its utility in the chemical industry.

InChI:InChI=1/C8H6O3/c9-4-6-1-2-8(11)7(3-6)5-10/h1-5,11H

Upstream product

• 23731-06-8 5-(chloromethyl)salicylaldehyde 
• 616-76-2 2-hydroxy-5-formylbenzoic acid 
• 67-66-3 chloroform 
• 123-08-0 4-hydroxy-benzaldehyde 
• 50-00-0 formaldehyd 
• 108-95-2 phenol 
• 100-97-0 hexamethylenetetramine 
• 90-02-8 salicylaldehyde 
• 20200-69-5 6-formyl-1',3',3'-trimethylspiro<2H-1-benzopyran-2,2'-<1H>-indole> 
• 89-95-2 2-methyl-benzyl alcohol 
• 404354-44-5 3-formyl-4-hydroxybenzoyl chloride 
• 1761-62-2 5-iodosalicyclaldehyde 
• 74901-08-9 5-hydroxymethylsalicylaldehyde 
• 7697-37-2 nitric acid 

Downstream Products

• 857477-51-1 5-chloromethyl-4-hydroxy-isophthalaldehyde 
• 186093-84-5 2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-carbaldehyde 
• 636-46-4 4-hydroxyisophthalic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 760984-01-8 4-(4-dodecyloxy-5-methoxy-2-nitrobenzyloxy)isophthalaldehyde 
• 760984-02-9 1-(4-dodecyloxy-5-methoxy-2-nitrobenzyloxy)-2,4-bis(3,5-diformylphenoxy)benzene 
• 915974-25-3 2,4-bis(2-hydroxybenzyl)phenol 
• 951656-22-7 trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester 
• 951656-23-8 trans-3-[2-(3,4,5-trimethoxybenzoyl)benzofuran-5-yl]acrylic acid tert-butyl ester 
• 951656-25-0 trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]acrylic acid 
• 951656-26-1 trans-3-[2-(3,4,5-trimethoxybenzoyl)benzofuran-5-yl]acrylic acid 
• 951656-28-3 trans-3-[2-(3-methoxybenzoyl)benzofuran-5-yl]-N-(tetrahydropyran-2-yloxy)acrylamide 
• 951656-29-4 trans-N-(tetrahydropyran-2-yloxy)-3-[2-(3,4,5-trimethoxybenzoyl)benzofuran-5-yl]acrylamide 

Relevant academic research and scientific papers

A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective

Rationally Optimized Fluorescent Probe for Imaging Mitochondrial SO2 in HeLa Cells and Zebrafish

Organisms have built up immunological systems, where mitochondrial SO2 plays conflicting roles in regulating cell apoptosis. However, no exploration on the influence and regulating principle of mitochondrial SO2 to the specific apoptosis type can be found, which brings about a challenge to fluorescent probes. Herein, we optimize the fluorophore and develop a new fluorescent probe FHMI ((E)-4-(3-formyl-4-hydroxystyryl)-1-methylpyridin-1-iumiodide) by equipping an ICT (intramolecular charge transfer) fluorophore HMII ((E)-4-(4-hydroxystyryl)-1-methylpyridin-1-ium iodide) with an aldehyde group that serves as both fluorescence quencher and reporting group. After the optimization, although the nonconjugated electron donor is formed when sensing SO2, the preset ICT fluorophore HMII is permitted to release the fluorescence at the enlarged wavelength. Compared with the traditional design, the probe FHMI exhibits obvious enhanced fluorescence with large red shift. FHMI is successfully applied to the mechanistic exploration of the dichotomous effects of mitochondrial SO2 to cells apoptosis, showing that mitochondrial SO2 regulates the early apoptosis of HeLa cells via the reduction of mitochondrial membrane potential. FHMI is applied to explore the dichotomous bioinfluence of mitochondrial SO2 to HeLa cells under oxidative stress, visualizing the regulative role of mitochondrial SO2 in the apoptotic process. For the first time, the mitochondrial SO2 is visually found to be closely associated with the early apoptosis of HeLa cells. Moreover, FHMI proves to be readily applicable to monitoring endogenous SO2 in zebrafish. This probe can act as an effective optical tool for exploring SO2 in biospecimen.

Synthesis, characterization, and UV–visible study of some new photochromic formyl-containing 1′,3′,3′-trimethylspiro[chromene-2,2′-indoline] derivatives

The spiropyran derivatives can exist in two forms, the closed-ring spiropyran form and the open-ring merocyanine (MC) form. The SP form could be converted into the MC form upon UV irradiation. In this work, some 1′,3′,3′-trimethylspiro[chromene-2,2′-indoline] derivatives containing the nitro and formyl groups are synthesized via the reaction of 1,3,3-trimethyl-2-methylene-5-nitroindoline with the corresponding salicylaldehyde derivatives. These compounds have different photochromic behaviors. The synthesized photochromic molecules are characterized by the FT-IR, 1H-NMR, and 13C-NMR spectroscopic techniques. In order to investigate the photochromic properties of these compounds, the UV–visible spectroscopic analyses of their methanolic solutions before and after exposure to a UV lamp (in the spectral range of 360–400?nm) are studied. Graphic abstract: [Figure not available: see fulltext.].

Fluorescent probe for fluorine ion detection, application of fluorescent probe and method for detecting fluorine ions in to-be-detected sample

The invention belongs to the technical field of analytical chemistry, and particularly relates to a fluorescent probe for fluorine ion detection, application of the fluorescent probe and a method for detecting fluorine ions in a to-be-detected sample. The invention provides a compound as shown in a formula I, or an optical isomer or salt thereof, and provides application of the compound as a fluorine ion detection fluorescent probe. According to the method for detecting the fluorine ions in the to-be-detected sample, the compound, or the optical isomer or the salt of the compound is used as a fluorine ion detection fluorescent probe for detection. The fluorescent probe has the advantages of good water solubility, high selectivity, high response speed, low detection limit, good stability, wide applicable pH range and good application prospect.

A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)

The disruption of copper homeostasis (Cu+/Cu2+) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu+ in physiological and pathological processes prompted the development of improved methods of Cu+ analysis. Herein, a new near-infrared (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu+ was developed based on a Cu+-mediated benzylic ether bond cleavage mechanism. The probe showed high selectivity and sensitivity toward Cu+, and was successfully applied for bioimaging of Cu+ in living cells. This journal is

Cyanine fluorescent probe as well as preparation method and application thereof

The invention discloses a cyanine fluorescent probe as well as a preparation method and application thereof. The fluorescent probe has a structure as shown in a structural general formula I, a one Doner-two Accepter structure is formed on a methine chain

'Triangle electron push-pull' mitochondria target type detection SO2 Fluorescent probe as well as preparation method and application thereof

The invention relates to a triangular electron push-pull chondriosome targeted SO2 detection fluorescence probe as well as a preparation method and application thereof. Phenol is dissolved into toluene and glacial acetic acid; under the catalysis effect o

Near-infrared fluorescent probe for measuring palladium ions based on cyanine structure and preparation method and application thereof

The invention provides a near-infrared fluorescent probe for measuring palladium ions based on a cyanine structure and a preparation method and application thereof, and the structural formula of the fluorescent probe is as defined in the specification. Th

NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery

A dual responsive NIRF turn-on protein delivery system incorporating an NIRF turn-on probe and protein into one single nanoparticle has been constructed. It can be taken up efficiently by A549 cells, where protein release and NIRF recovery happen simultaneously in response to low pH and excessive H2O2. This work provides a novel system for monitoring intracellular protein delivery.

Fluorescent probe for detecting fluoride ions

The invention discloses a fluorescent probe for detecting fluoride ions in an organism, and belongs to the technical field of analytical chemistry. The fluorescent probe uses a cyanine dye QCy7 as a parent body, a silicon-oxygen bond as a switch and hydroxybenzyl as a linker, and the chemical structure general formula of the fluorescent probe is as shown in a formula (I). The fluorescent probe hassimple synthesis and is convenient to use, can specifically react with the fluoride ions, breaks the silicon-oxygen bond, and releases fluorescence of fluorogen QCy7 through electron transfer. The fluorescent probe is not interfered with other ions in the process of detecting the fluoride ions, has good selectivity to the fluoride ions, and can accurately detect the fluoride ions in the organism.