1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Base Information

Chemical Name:1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide
CAS No.:1207202-99-0
Molecular Formula:C₃₃H₂₉Cl₂F₃N₂O₂S₂
Molecular Weight:677.639
Hs Code.:

Synonyms:1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

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Chemical Property of 1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

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Technology Process of 1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

There total 4 articles about 1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56243-25-5
1-benzyl-4-cyano-4-phenylpiperidine

: 1207202-99-0
1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sulfuric acid / 1 h / 100 °C

1.2: Cooling with ice

2.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

4.1: sodium hydride / xylene / 1.25 h / 0 - 20 °C / Inert atmosphere

4.2: 150 °C

With sulfuric acid; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; xylene;

Reference yield:

: 170655-60-4
4,4,4-trifluorobutane-1-thiol

: 1207203-52-8
1-{[4-(4-bromophenyl)-5-(2,4-dichlorophenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

: 1207202-99-0
1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: 4,4,4-trifluorobutane-1-thiol; With sodium hydride; In xylene; at 0 - 20 ℃; for 1.25h; Inert atmosphere;

1-{[4-(4-bromophenyl)-5-(2,4-dichlorophenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In xylene; at 150 ℃;

Reference yield:

: 59084-07-0
1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide; hydrochloride

: 1207202-99-0
1-{[5-(2,4-Dichlorophenyl)-4-{4-[(4,4,4-trifluorobutyl)thio]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

2.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

3.1: sodium hydride / xylene / 1.25 h / 0 - 20 °C / Inert atmosphere

3.2: 150 °C

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; xylene;