1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide

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Chemical Name:1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide
CAS No.:1307801-83-7
Molecular Formula:C₂₀H₂₄N₆O₂
Molecular Weight:380.45
Hs Code.:

Synonyms:1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide

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Chemical Property of 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide

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Technology Process of 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide

There total 5 articles about 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 1307801-58-6
1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carboxylic acid

: 1307801-83-7
1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide

Guidance literature:: 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

(2-hydroxyethyl)(methyl)amine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1307801-57-5
ethyl 1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carboxylate

: 1307801-83-7
1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; ethanol / 2 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 3 h / 20 °C

With ethanol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 85290-78-4,861585-81-1
ethyl 3-methylpyrazole-4-carboxylate

: 1307801-83-7
1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-N-(2-hydroxyethyl)-N,3-dimethyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 8 h / 80 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3.1: acetic acid / butan-1-ol / 2 h / Reflux

4.1: sodium hydroxide; ethanol / 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 3 h / 20 °C

With ethanol; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;