(25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

Base Information

Chemical Name:(25R)-5α-spirostan-2α-O-benzyloxy-3β-ol
CAS No.:885453-85-0
Molecular Formula:C₃₄H₅₀O₄
Molecular Weight:522.769
Hs Code.:

Synonyms:(25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

Suppliers and Price of (25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

Chemical Property:

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Technology Process of (25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

There total 7 articles about (25R)-5α-spirostan-2α-O-benzyloxy-3β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 512-04-9
diosgenin

: 885453-85-0
(25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 93 percent / H₂; AcOH / Pd/C / CH₂Cl₂; ethanol / 12 h / 20 °C / 760 Torr

2.1: pyridine / 20 °C

3.1: 7.12 g / silica gel / CHCl₃; petroleum ether / 48 h / 20 °C

4.1: 74 percent / aq. N-methylmorpholine N-oxide; OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 20 °C

5.1: Bu₂SnO / toluene / 6 h / Heating

5.2: 98 percent / Bu₄N(+)*I(-) / toluene / 2.5 h / Heating

6.1: Dess-Martin periodinane / CH₂Cl₂ / 12 h / 20 °C

7.1: 4.61 g / CeCl₃*7H₂O; NaBH₄ / tetrahydrofuran; methanol / 2 h / -40 °C

With pyridine; sodium tetrahydroborate; osmium(VIII) oxide; cerium(III) chloride; hydrogen; silica gel; di(n-butyl)tin oxide; Dess-Martin periodane; acetic acid; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; toluene; Petroleum ether; tert-butyl alcohol;
DOI:10.1055/s-2006-926316

Reference yield:

: 885453-84-9
C₃₄H₄₈O₄

: 885453-83-8
(25R)-5α-spirostan-2α-O-benzyloxy-3α-ol

: 885453-85-0
(25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In tetrahydrofuran; methanol; at -40 ℃; for 2h;
DOI:10.1055/s-2006-926316

Reference yield:

: 39636-32-3
O-(toluene-4-sulfonyl)-tigogenin

: 885453-85-0
(25R)-5α-spirostan-2α-O-benzyloxy-3β-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 7.12 g / silica gel / CHCl₃; petroleum ether / 48 h / 20 °C

2.1: 74 percent / aq. N-methylmorpholine N-oxide; OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 20 °C

3.1: Bu₂SnO / toluene / 6 h / Heating

3.2: 98 percent / Bu₄N(+)*I(-) / toluene / 2.5 h / Heating

4.1: Dess-Martin periodinane / CH₂Cl₂ / 12 h / 20 °C

5.1: 4.61 g / CeCl₃*7H₂O; NaBH₄ / tetrahydrofuran; methanol / 2 h / -40 °C

With sodium tetrahydroborate; osmium(VIII) oxide; cerium(III) chloride; silica gel; di(n-butyl)tin oxide; Dess-Martin periodane; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; chloroform; toluene; Petroleum ether; tert-butyl alcohol;
DOI:10.1055/s-2006-926316