N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine

Base Information

Chemical Name:N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine
CAS No.:1415346-03-0
Molecular Formula:C₂₂H₂₉FN₂OSi
Molecular Weight:384.569
Hs Code.:

Synonyms:N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine

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Chemical Property of N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine

Chemical Property:

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Technology Process of N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine

There total 6 articles about N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415346-02-9
6-fluoro-1-phenyl-1H-indol-5-yl trifluoromethanesulfonate

: 101711-55-1
2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine

: 1415346-03-0
N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine

Guidance literature:: With caesium carbonate; XPhos; palladium diacetate; In toluene; at 120 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 63762-83-4
5-methoxy-6-fluoroindole

: 1415346-03-0
N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(I) bromide; potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 100 °C

1.2: 16 h / 110 °C

2.1: pyridine hydrochloride / 6 h / 160 °C / seal tube

3.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

4.1: caesium carbonate; XPhos / palladium diacetate / toluene / 2.5 h / 120 °C / Inert atmosphere

With pyridine; pyridine hydrochloride; potassium carbonate; caesium carbonate; copper(I) bromide; XPhos; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: buchwald reaction;

Reference yield:

: 455-93-6
2-fluoro-1-methoxy-4-nitrobenzene

: 1415346-03-0
N-(2-(tert-butyldimethylsilyloxy)ethyl)-6-fluoro-1-phenyl-1H-indol-5-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / -20 °C

2.1: hydrogen / palladium on activated charcoal / 3 h / 27 °C

3.1: copper(I) bromide; potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 100 °C

3.2: 16 h / 110 °C

4.1: pyridine hydrochloride / 6 h / 160 °C / seal tube

5.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

6.1: caesium carbonate; XPhos / palladium diacetate / toluene / 2.5 h / 120 °C / Inert atmosphere

With pyridine; potassium tert-butylate; hydrogen; pyridine hydrochloride; potassium carbonate; caesium carbonate; copper(I) bromide; XPhos; palladium on activated charcoal; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; toluene; 6.1: buchwald reaction;