Technology Process of N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(6-fluoro-1-phenyl-1H-indol-5-yl)pyrimidine-5-carboxamide
There total 7 articles about N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(6-fluoro-1-phenyl-1H-indol-5-yl)pyrimidine-5-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: copper(I) bromide; potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 100 °C
1.2: 16 h / 110 °C
2.1: pyridine hydrochloride / 6 h / 160 °C / seal tube
3.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice
4.1: caesium carbonate; XPhos / palladium diacetate / toluene / 2.5 h / 120 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 1 h / 0 °C
With
pyridine; pyridine hydrochloride; potassium carbonate; caesium carbonate; triethylamine; copper(I) bromide; XPhos;
palladium diacetate;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
4.1: buchwald reaction;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / -20 °C
2.1: hydrogen / palladium on activated charcoal / 3 h / 27 °C
3.1: copper(I) bromide; potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 100 °C
3.2: 16 h / 110 °C
4.1: pyridine hydrochloride / 6 h / 160 °C / seal tube
5.1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice
6.1: caesium carbonate; XPhos / palladium diacetate / toluene / 2.5 h / 120 °C / Inert atmosphere
7.1: triethylamine / dichloromethane / 1 h / 0 °C
With
pyridine; potassium tert-butylate; hydrogen; pyridine hydrochloride; potassium carbonate; caesium carbonate; triethylamine; copper(I) bromide; XPhos;
palladium on activated charcoal; palladium diacetate;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
6.1: buchwald reaction;
