455-93-6

Basic information

• Product Name: 2-Fluoro-4-nitroanisole
• Synonyms: 2-FLUORO-4-NITROANISOLE;2-Fluoro-4-nitro-methoxybenzene;2-fluoro-1-methoxy-4-nitrobenzene;2-Fluoro-4-nitroanisole 98%;2-Fluoro-4-nitroanisole98%;1-Methoxy-2-fluoro-4-nitrobenzene;2-Methoxy-5-nitro-1-fluorobenzene;2-Fluoro-4-nitroanis
• CAS NO: 455-93-6
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.13
• Product Categories: Amines;blocks;Aromatic Halides (substituted);AnisoleSeries;Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Nitro Compounds;Benzenes;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 455-93-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 103-105 °C(lit.)
• Boiling Point: 277.167 °C at 760 mmHg
• Flash Point: 121.427 °C
• Appearance: White to light yellow/Crystalline Powder
• Density: 1.322 g/cm³
• Vapor Pressure: 0.000519mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Toluene
• CAS DataBase Reference: 2-Fluoro-4-nitroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-nitroanisole(455-93-6)
• EPA Substance Registry System: 2-Fluoro-4-nitroanisole(455-93-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 455-93-6(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystalline powder

Uses

2-Fluoro-4-nitroanisole was employed as alternative biochemical photoprobe for proteins.

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o

General Description

2-Fluoro-4-nitroanisole is a 2-halo-4-nitroanisole and its photoreaction with the nucleophiles hydroxide ion and pyridine has been investigated. Mechanism of photoreaction of 2-fluoro-4-nitroanisole with n-hexylamine has been investigated.

InChI:InChI=1/C7H7FN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 350-31-2 1-chloro-2-fluoro-4-nitrobenzene 
• 124-41-4 sodium methylate 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 67-56-1 methanol 
• 369-34-6 3,4-difluoronitrobenzene 
• 1825-61-2 Trimethylmethoxysilane 
• 403-20-3 3-fluoro-p-anisic acid 
• 403-19-0 2-fluoro-4-nitrophenol 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 367-11-3 ortho-difluorobenzene 
• 100-17-4 para-methoxynitrobenzene 

Downstream Products

• 709-09-1 3,4-dimethoxynitrobenzene 
• 636-93-1 5-nitroguaiacol 
• 124431-95-4 N-hexyl-2-fluoro-4-nitroaniline 
• 114568-54-6 N-(1-hexyl)-2-methoxy-5-nitroaniline 
• 10496-75-0 2-methoxy-5-nitrobenzylnitrile 
• 331-62-4 3-fluoro-4-methoxybenzonitrile 
• 1101862-59-2 C₁₄H₁₂FNO₅S 
• 366-99-4 3-fluoro-4-methoxyaniline 
• 344-78-5 6-fluoro-2,4-dinitroanisole 
• 403-19-0 2-fluoro-4-nitrophenol 
• 452-15-3 N-(3-fluoro-4-methoxyphenyl)acetamide 
• 1415345-12-8 4-amino-6-(6-fluoro-1-phenyl-1H-indol-5-yl)-7,8-dihydrooxazepino[2,3-d]pyrimidin-5(6H)-one 
• 1415346-06-3 4-chloro-6-(6-fluoro-1-phenyl-1H-indol-5-yl)-7,8-dihydrooxazepino[2,3-d]pyrimidin-5(6H)-one 
• 1415346-05-2 4,6-dichloro-N-(6-fluoro-1-phenyl-1H-indol-5-yl)-N-(2-hydroxyethyl)pyrimidine-5-carboxamide 

Relevant articles and documents

Anodic fluorination of 4-methoxy-1-naphthol and 4-nitroanisole using Et3N · 5 HF in mixed nonaqueous solvent

Anodic fluorination of 4-methoxy-1-naphthol and 4-nitroanisole has been investigated in a mixed nonaqueous solvent using Et3N · 5 HF as supporting electrolyte as well as fluorine source. In order to avoid the formation of polymer on the anode,

Method for preparing alkyloxy aromatic compound from fluoroaromatic compound

The invention discloses a method for preparing an alkyloxy aromatic compound from a fluoroaromatic compound. The alkyloxy aromatic compound is highly-efficiently prepared through a reaction of the fluoroaromatic compound, a strong alkali, dimethyl sulfoxide and alcohol under certain conditions. The method has the advantages of no metal catalyst, mild and controllable reaction, simple process, good universality, and suitableness for large-scale industrial production.

Fluorination of aromatic compounds with xenon difluoride in the presence of boron trifluoride etherate

Fluorination of benzene with the XeF2 - BF3?Et2O system in acetonitrile at low temperatures affords fluorobenzene in 18% yield, the conversion of benzene being 92%. The rest products are di-, tri-, tetra-, and polyphenyls with different fluorination pattern. Toluene and chloro- and bromobenzenes are fluorinated predominantly at the ortho and para positions. Fluorination of 4-nitroanisole affords 2-fluoro-4-nitroanisole in 73% yield.