benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

Base Information

Chemical Name:benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate
CAS No.:1133931-73-3
Molecular Formula:C₂₅H₃₁ClN₂O₅
Molecular Weight:474.985
Hs Code.:

Synonyms:benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

Suppliers and Price of benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
6-Chloro-N-[(1,1-dimethylethoxy)carbonyl]-5-[(phenylmethoxy)imino]-L-norleucinePhenylmethylEster
10mg
$ 45.00

Total 2 raw suppliers

Chemical Property of benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

6-Chloro-N-[(1,1-dimethylethoxy)carbonyl]-5-[(phenylmethoxy)imino]-L-norleucinePhenylmethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 6-Chloro-N-[(1,1-dimethylethoxy)carbonyl]-5-[(phenylmethoxy)imino]-L-norleucine Phenylmethyl Ester is used as a reactant in the synthesis of Avibactam.

Technology Process of benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

There total 2 articles about benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: benzyl (2S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 1133931-73-3
benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

Guidance literature:: benzyl (2S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ⁶-sulfanylidene)-5-oxohexanoate; With methanesulfonic acid; lithium chloride; In tetrahydrofuran; at 20 - 50 ℃; for 5h;

O-benzylhydoxylamine hydrochloride; With sodium acetate; In tetrahydrofuran; water; ethyl acetate; at 20 ℃; for 18h;

Reference yield:

: 113400-36-5,400626-71-3
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

: 1133931-73-3
benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C

1.2: -12 °C

2.1: ethyl acetate / Reflux

With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate;