(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt

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Chemical Name:(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt
CAS No.:1173158-98-9
Molecular Formula:CH₂O₂*C₁₉H₃₁N₃O₄
Molecular Weight:411.499
Hs Code.:

Synonyms:(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt

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Chemical Property of (2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt

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Technology Process of (2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt

There total 6 articles about (2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.7%

: 64-18-6
formic acid

: 1173158-96-7
(2R)-2-[(tert-butoxy)carbonylamino]-4-methyl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)pentanamide

: 1173158-98-9
(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt

Guidance literature:: (2R)-2-[(tert-butoxy)carbonylamino]-4-methyl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)pentanamide; With diethylamine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In water; acetonitrile; at 22 ℃; for 0.5h;

formic acid; In water; acetonitrile;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1173158-98-9
(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h

3.1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / tetrahydrofuran / 28 h / 0 - 50 °C / Inert atmosphere

4.1: hydrazine hydrate / methanol / 0.5 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 22 °C

6.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.5 h / 22 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 6.1: Haller-Bauer Reaction;

Reference yield:

: 1173158-94-5
N-({4-[(1,3-dioxoisoindolin-2-yloxy)methyl]phenyl}methyl)prop-2-enyloxycarboxamide

: 1173158-98-9
(2R)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-methylpentanamide formic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 0.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 22 °C

3: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.5 h / 22 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; diethylamine; N-ethyl-N,N-diisopropylamine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In methanol; water; N,N-dimethyl-formamide; acetonitrile; 3: Haller-Bauer Reaction;