methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate

Base Information

• Chemical Name: methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate
• CAS No.: 169124-33-8
• Molecular Formula: C₂₄H₂₈O₃
• Molecular Weight: 364.485
• Mol file: 169124-33-8.mol

Synonyms:methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate

Chemical Property of methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate

There total 1 articles about methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1,1,2,3,3,6-hexamethyl-1H-indane (4834-28-0) + 4-Methoxycarbonylbenzoyl chloride (7377-26-6) → methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate (169124-33-8)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 0.166667h; Ambient temperature;

DOI:10.1021/jm00016a018

Reference yield:

methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate (169124-33-8) → 4-[1-(1,1,2,3,3,6-Hexamethyl-indan-5-yl)-vinyl]-benzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaNH₂ / 1.) THF, RT, 5 h, 2.) THF, 20 min

2: 81 percent / 5N aq. KOH / methanol / Heating

With potassium hydroxide; sodium amide; In methanol;

DOI:10.1021/jm00016a018

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)carbonyl>benzoate (169124-33-8) → methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)ethenyl>benzoate (169124-34-9)

Guidance literature:

With sodium amide; Yield given. Multistep reaction; 1.) THF, RT, 5 h, 2.) THF, 20 min;

DOI:10.1021/jm00016a018

upstream raw materials:

1,1,2,3,3,6-hexamethyl-1H-indane

4-Methoxycarbonylbenzoyl chloride

Downstream raw materials:

methyl 4-<(1,1,2,3,3,6-hexamethylindan-5-yl)ethenyl>benzoate