Technology Process of 6-cyclopropylmethyl-7-ethyl-2-(4-isopropenyl-2-trifluoromethyl-phenyl)-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylene
There total 11 articles about 6-cyclopropylmethyl-7-ethyl-2-(4-isopropenyl-2-trifluoromethyl-phenyl)-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
magnesium sulfate; toluene-4-sulfonic acid; trifluoroacetic acid;
In
toluene;
for 16h;
Heating;
DOI:10.1021/jm049085v
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 95 percent / phosphorus oxychloride / acetonitrile / 3 h / Heating
2.1: 98 percent / bromine / aq. methanol / 0.5 h
3.1: p-toluenesulfonic acid / 16 h / 150 °C
4.1: 9.8 g / aq. hydrobromic acid / 72 h / 120 °C
5.1: NaH / dimethylformamide / 0.25 h / 20 °C
5.2: 64 percent / dimethylformamide / 1 h / 20 °C
6.1: 3.78 g / aq. sodium carbonate; barium hydroxide; Pd(PPh3)4 / toluene; ethanol / 100 °C
7.1: tetrahydrofuran; toluene / 2.5 h / 20 - 60 °C
8.1: 45 percent / MgSO4; p-toluenesulfonic acid; trifluoroacetic acid / toluene / 16 h / Heating
With
barium dihydroxide; tetrakis(triphenylphosphine) palladium(0); hydrogen bromide; bromine; sodium hydride; sodium carbonate; magnesium sulfate; toluene-4-sulfonic acid; trifluoroacetic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
6.1: Suzuki coupling;
DOI:10.1021/jm049085v
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 98 percent / bromine / aq. methanol / 0.5 h
2.1: p-toluenesulfonic acid / 16 h / 150 °C
3.1: 9.8 g / aq. hydrobromic acid / 72 h / 120 °C
4.1: NaH / dimethylformamide / 0.25 h / 20 °C
4.2: 64 percent / dimethylformamide / 1 h / 20 °C
5.1: 3.78 g / aq. sodium carbonate; barium hydroxide; Pd(PPh3)4 / toluene; ethanol / 100 °C
6.1: tetrahydrofuran; toluene / 2.5 h / 20 - 60 °C
7.1: 45 percent / MgSO4; p-toluenesulfonic acid; trifluoroacetic acid / toluene / 16 h / Heating
With
barium dihydroxide; tetrakis(triphenylphosphine) palladium(0); hydrogen bromide; bromine; sodium hydride; sodium carbonate; magnesium sulfate; toluene-4-sulfonic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
5.1: Suzuki coupling;
DOI:10.1021/jm049085v
![2-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6<i>H</i>-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-propan-2-ol](/Databaselist/images/loading.webp)
