2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Chemical Name:2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid
CAS No.:1610370-39-2
Molecular Formula:C₂₈H₂₆F₄N₂O₃
Molecular Weight:514.52
Hs Code.:

Synonyms:2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Chemical Property of 2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Technology Process of 2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

There total 13 articles about 2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1610370-50-7
methyl 2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

: 1610370-39-2
2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3.5h;

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 1610370-39-2
2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

3.2: 1.33 h / 90 °C

4.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

7.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

8.1: silver carbonate / 1,4-dioxane / 41 h / 50 - 55 °C / Inert atmosphere

9.1: sodium tetrahydroborate / tetrahydrofuran; water / 1.5 h / 20 °C

10.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

11.1: dimethyl sulfoxide / 5.8 h / 60 °C

12.1: hydrogenchloride / dichloromethane; acetic acid methyl ester / 25 h / 20 - 35 °C

13.1: water; lithium hydroxide / tetrahydrofuran / 3.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; oxalyl dichloride; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; caesium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; toluene-4-sulfonic acid hydrazide; silver carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid methyl ester; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 24078-12-4
4-bromo-2-methylbenzaldehyde

: 1610370-39-2
2-((4S,5S)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

2.2: 1.33 h / 90 °C

3.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

6.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

7.1: silver carbonate / 1,4-dioxane / 41 h / 50 - 55 °C / Inert atmosphere

8.1: sodium tetrahydroborate / tetrahydrofuran; water / 1.5 h / 20 °C

9.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

10.1: dimethyl sulfoxide / 5.8 h / 60 °C

11.1: hydrogenchloride / dichloromethane; acetic acid methyl ester / 25 h / 20 - 35 °C

12.1: water; lithium hydroxide / tetrahydrofuran / 3.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; toluene-4-sulfonic acid hydrazide; silver carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid methyl ester; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;