(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate

Base Information

• Chemical Name: (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate
• CAS No.: 1286180-98-0
• Molecular Formula: C₂₃H₂₇BrFNO₅S
• Molecular Weight: 528.439
• Mol file: 1286180-98-0.mol

Synonyms:(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate

Chemical Property of (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate

There total 5 articles about (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine (681247-87-0,681247-88-1) + methyl 3-bromo-6-(2-bromo-4-fluorobenzenesulphonylmethyl)-2-methoxybenzoate (1286181-00-7) → (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate (1286180-98-0)

Guidance literature:

With cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; Inert atmosphere; Reflux;

Reference yield:

methyl 3-bromo-2-methoxy-6-methylbenzoate → (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate (1286180-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 0.67 h / 90 °C

2.1: potassium carbonate / tetrahydrofuran / 1 h / Reflux

2.2: 2 h / 20 - 80 °C

3.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield:

methyl 3-bromo-6-bromomethyl-2-methoxybenzoate (1286179-94-9) → (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate (1286180-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / 20 - 80 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

With potassium carbonate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;

upstream raw materials:

N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

methyl 3-bromo-6-(2-bromo-4-fluorobenzenesulphonylmethyl)-2-methoxybenzoate

methyl 3-bromo-6-bromomethyl-2-methoxybenzoate

methyl 3-bromo-2-hydroxy-6-methylbenzoate

Downstream raw materials:

(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-hydroxybenzoate

7-[2-(Z)-(3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylic acid

C₂₇H₂₈FNO₆S

C₂₇H₂₈FNO₆S