methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

Base Information

Chemical Name:methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate
CAS No.:1356112-94-1
Molecular Formula:C₂₈H₃₀FNO₆S
Molecular Weight:527.614
Hs Code.:

Synonyms:methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

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Chemical Property of methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

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Technology Process of methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

There total 10 articles about methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356112-98-5
methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

: 1356112-94-1
methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 10 - 20 ℃; for 0.75h;

Reference yield:

: 681247-87-0,681247-88-1
N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

: 1356112-94-1
methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

2: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

3: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

4: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 10 - 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 10 - 20 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; caesium carbonate; N,N-dimethyl-aniline; triphenylphosphine; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1286179-94-9
methyl 3-bromo-6-bromomethyl-2-methoxybenzoate

: 1356112-94-1
methyl 7-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / 20 - 80 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

3.1: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

4.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

5.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 10 - 20 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 10 - 20 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium carbonate; caesium carbonate; N,N-dimethyl-aniline; triphenylphosphine; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;