ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate
CAS No.:1561965-02-3
Molecular Formula:C₃₀H₄₃NO₃
Molecular Weight:465.676
Hs Code.:

Synonyms:ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

There total 7 articles about ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1561964-55-3
ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

: 74-88-4
methyl iodide

: 1561965-02-3
ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561965-02-3
ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / Reflux; Inert atmosphere

2.1: tetrahydrofuran / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydride; In tetrahydrofuran; toluene;

Reference yield:

: 1561964-53-1
ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561965-02-3
ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

With sodium hydride; In tetrahydrofuran;