Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester
CAS No.:270087-95-1
Molecular Formula:C₃₃H₃₂Cl₃NO₈S
Molecular Weight:709.044
Hs Code.:

Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

Synonyms:Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

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Chemical Property of Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

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Technology Process of Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

There total 1 articles about Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: ((2R,4aR,6R,7R,8R,8aS)-6-Ethylsulfanyl-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-carbamic acid 2,2,2-trichloro-ethyl ester

: 270087-95-1
Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: With pyridine;
DOI:10.1016/S0957-4166(99)00569-8

Reference yield: 94.0%

: 270087-95-1
Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

: 270087-96-2
ethyl 6-O-benzyl-3-O-(9-fluorenylmethoxycarbonyl)-2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1-thio-α-D-glucopyranoside

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0957-4166(99)00569-8

Reference yield:

: 270087-95-1
Carbonic acid (2R,4aR,6R,7R,8R,8aS)-6-ethylsulfanyl-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 9H-fluoren-9-ylmethyl ester

: ethyl 6-O-benzyl-4-O-levulinoyl-2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1-thio-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / HCl; NaCNBH₃; 3A MS / diethyl ether; tetrahydrofuran

2: 98 percent / DCC; DMAP / CH₂Cl₂ / 1 h

3: 99 percent / triethylamine / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; sodium cyanoborohydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Ring cleavage / 2: Esterification / 3: Deesterification;
DOI:10.1016/S0957-4166(99)00569-8