2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Base Information

• Chemical Name: 2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
• CAS No.: 1131890-97-5
• Molecular Formula: C₁₁H₆ClF₉O₄S
• Molecular Weight: 440.671
• Mol file: 1131890-97-5.mol

Synonyms:2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Chemical Property of 2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

There total 1 articles about 2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Nonafluorobutanesulfonyl fluoride (375-72-4) + 2-chloro-4-methoxyphenol (18113-03-6) → 2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (1131890-97-5)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield: 99.0%

2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (1131890-97-5) + 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide (60672-33-5) → 2-chloro-4-methoxy-1-(1-(p-tolyl)vinyl)benzene (1262210-20-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; lithium tert-butoxide; XPhos; In 1,4-dioxane; at 110 ℃; regioselective reaction; Inert atmosphere; Reflux;

DOI:10.1021/ol102884g

Reference yield: 92.0%

2-chloro-4-methoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (1131890-97-5) + N'-(1-(4-methoxyphenyl)propylidene)-4-methylbenzenesulfonohydrazide (424811-46-1) → (Z)-2-chloro-4-methoxy-1-(1-(4-methoxyphenyl)prop-1-en-1-yl)benzene (1262210-31-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; lithium chloride; lithium tert-butoxide; XPhos; In 1,4-dioxane; at 110 ℃; for 15h; Inert atmosphere; Reflux;

DOI:10.1021/ol102884g

upstream raw materials:

Nonafluorobutanesulfonyl fluoride

2-chloro-4-methoxyphenol

Downstream raw materials:

6-methoxy-1,2-diphenyl-1H-indole

6-methoxy-1-(4-methoxyphenyl)-2-phenyl-1H-indole

(Z)-2-chloro-4-methoxy-1-(1-(4-methoxyphenyl)prop-1-en-1-yl)benzene

2'-chloro-2,4'-dimethoxy-2,3,4,5-tetrahydro-1,1'-biphenyl

Refernces

• 1、 Barluenga, Jose,Jimenez-Aquino, Agustin,Aznar, Fernando,Valdes, Carlos. "Modular synthesis of indoles from imines and o-dihaloarenes or o-chlorosulfonates by a Pd-catalyzed cascade process". supporting information; experimental part. p. 4031 - 4041. Retrieved 2009/09/04.