(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime

Base Information

Chemical Name:(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime
CAS No.:871841-10-0
Molecular Formula:C₁₆H₂₄F₃NO₂Si
Molecular Weight:347.453
Hs Code.:

Synonyms:(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime

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Chemical Property of (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime

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Technology Process of (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime

There total 4 articles about (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 871841-07-5
(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

: 871841-10-0
(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In ethanol; at 80 ℃; for 4h;
DOI:10.1016/j.tet.2005.09.007

Reference yield:

: 871841-05-3
(S)-1-(3-bromophenyl)ethyl alcohol-O-(tert-butyldimethylsilyl) ether

: 871841-10-0
(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1.25 h / -78 °C

1.2: 91 percent / tetrahydrofuran; hexane / 1.25 h / -78 °C

2.1: 99 percent / hydroxylamine hydrochloride; pyridine / ethanol / 4 h / 80 °C

With pyridine; n-butyllithium; hydroxylamine hydrochloride; In tetrahydrofuran; ethanol; hexane;
DOI:10.1016/j.tet.2005.09.007

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 871841-10-0
(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / NaH; 15-crown-5 / CH₂Cl₂; various solvent(s) / 0.92 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.25 h / -78 °C

2.2: 91 percent / tetrahydrofuran; hexane / 1.25 h / -78 °C

3.1: 99 percent / hydroxylamine hydrochloride; pyridine / ethanol / 4 h / 80 °C

With pyridine; n-butyllithium; 15-crown-5; hydroxylamine hydrochloride; sodium hydride; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1016/j.tet.2005.09.007