(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

Base Information

Chemical Name:(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone
CAS No.:871841-07-5
Molecular Formula:C₁₆H₂₃F₃O₂Si
Molecular Weight:332.438
Hs Code.:

Synonyms:(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

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Chemical Property of (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

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Technology Process of (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

There total 3 articles about (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 871841-05-3
(S)-1-(3-bromophenyl)ethyl alcohol-O-(tert-butyldimethylsilyl) ether

: 360-92-9
N,N-diethyl-2,2,2-trifluoroacetamide

: 871841-07-5
(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

Guidance literature:: (S)-1-(3-bromophenyl)ethyl alcohol-O-(tert-butyldimethylsilyl) ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.25h;

N,N-diethyl-2,2,2-trifluoroacetamide; In tetrahydrofuran; hexane; at -78 ℃; for 1.25h;
DOI:10.1016/j.tet.2005.09.007

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 871841-07-5
(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / NaH; 15-crown-5 / CH₂Cl₂; various solvent(s) / 0.92 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.25 h / -78 °C

2.2: 91 percent / tetrahydrofuran; hexane / 1.25 h / -78 °C

With n-butyllithium; 15-crown-5; sodium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2005.09.007

Reference yield:

: 134615-22-8
(S)-1-(3-bromophenyl)ethan-1-ol

: 871841-07-5
(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / NaH; 15-crown-5 / CH₂Cl₂; various solvent(s) / 0.92 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.25 h / -78 °C

2.2: 91 percent / tetrahydrofuran; hexane / 1.25 h / -78 °C

With n-butyllithium; 15-crown-5; sodium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2005.09.007