tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate
CAS No.:1207438-73-0
Molecular Formula:C₁₈H₂₅Cl₂NO₃
Molecular Weight:374.307
Hs Code.:

Synonyms:tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

There total 11 articles about tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 4-(1-(3,4-dichlorophenyl)-2-oxoethyl)piperidine-1-carboxylate

: 1207438-75-2
tert-butyl 4-[(1S)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

: 1207438-73-0
tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

Guidance literature:: With [((R)-Xyl-BINAP)((R,R)-DPEN)RuCl₂]; potassium tert-butylate; hydrogen; In isopropyl alcohol; tert-butyl alcohol; at 50 ℃; for 2h; under 7500.75 Torr; Reagent/catalyst; Pressure; enantioselective reaction;
DOI:10.1016/j.tetasy.2015.06.021

Reference yield:

: 1207438-71-8
tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

: 1207438-75-2
tert-butyl 4-[(1S)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

: 1207438-73-0
tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

Guidance literature:: With CHIRALPAK AD; In hexane; isopropyl alcohol; at 30 ℃; Resolution of racemate;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-43-4
tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate

: 1207438-73-0
tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-hydroxyethyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; water / 5 h / Reflux

2.1: sodium hydroxide / water

2.2: 20 h / 20 °C

2.3: pH Ca_. 3

3.1: borane-THF / tetrahydrofuran / 20 - 70 °C

4.1: CHIRALPAK AD / hexane; isopropyl alcohol / 30 °C / Resolution of racemate

With borane-THF; water; hydrogen bromide; sodium hydroxide; In tetrahydrofuran; hexane; water; isopropyl alcohol;
DOI:10.1016/j.bmc.2013.05.025