2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid

Base Information

Chemical Name:2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid
CAS No.:1415089-57-4
Molecular Formula:C₂₃H₂₂F₅N₅O₂*H₃O₄P
Molecular Weight:593.447
Hs Code.:

Synonyms:2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid

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Chemical Property of 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid

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Technology Process of 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid

There total 15 articles about 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1415089-24-5
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

: 1415089-57-4
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid

Guidance literature:: With phosphoric acid; In acetonitrile; at 20 ℃; for 0.833333h; Product distribution / selectivity;

Reference yield:

: 1415089-65-4
ethyl 5-cyano-2-(difluoromethyl)nicotinate

: 1415089-57-4
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 1.17 h / 20 °C / 3102.97 Torr / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 18 - 22 °C

3.1: water; lithium hydroxide / 1,4-dioxane / 1 h / 20 °C

3.2: 20 °C / pH 2

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 75 °C

5.1: phosphoric acid / acetonitrile / 0.83 h / 20 °C

With hydrogenchloride; phosphoric acid; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; 5%-palladium/activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1346535-38-3
ethyl 5-bromo-2-formylnicotinate

: 1415089-57-4
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 19 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

3.1: triethylamine; hydrogen / potassium fluoride; 5%-palladium/activated carbon / ethanol / 14.5 h / 2250.23 - 3000.3 Torr / autoclave; Industry scale

4.1: hydrogenchloride; water / dichloromethane; 1,4-dioxane; tert-butyl methyl ether / 20 - 30 °C / Industry scale

5.1: triethylamine / toluene / 1.25 h / 0 - 20 °C / Industry scale

5.2: 15 - 25 °C

5.3: 1.6 h / 15 - 25 °C / pH 3.5 - 4.5

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 75 °C

7.1: phosphoric acid / acetonitrile / 0.83 h / 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; phosphoric acid; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In 1,4-dioxane; ethanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; toluene; acetonitrile;