2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Base Information

Chemical Name:2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide
CAS No.:1415089-24-5
Molecular Formula:C₂₃H₂₂F₅N₅O₂
Molecular Weight:495.452
Hs Code.:

Synonyms:2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

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Chemical Property of 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

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Technology Process of 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

There total 15 articles about 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.43%

: 1415089-72-3
2-(difluoromethyl)-5-(isobutyramidomethyl)nicotinic acid

: [4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]ammonium formate

: 1415089-24-5
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield: 66.0%

: 1415089-74-5
4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-amine

: 1415089-72-3
2-(difluoromethyl)-5-(isobutyramidomethyl)nicotinic acid

: 1415089-24-5
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 75 ℃; for 18h; Product distribution / selectivity;

Reference yield:

: 1415089-65-4
ethyl 5-cyano-2-(difluoromethyl)nicotinate

: 1415089-24-5
2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 1.17 h / 20 °C / 3102.97 Torr / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 18 - 22 °C

3.1: water; lithium hydroxide / 1,4-dioxane / 1 h / 20 °C

3.2: 20 °C / pH 2

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 75 °C

With hydrogenchloride; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; 5%-palladium/activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;