5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril

Base Information

Chemical Name:5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril
CAS No.:128232-11-1
Molecular Formula:C₂₁H₂₃IN₂O₃
Molecular Weight:478.33
Hs Code.:

Synonyms:5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril

Chemical Property:

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Technology Process of 5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril

There total 12 articles about 5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128232-09-7
8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

: 128232-11-1
5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 5h; under 2585.7 Torr;
DOI:10.1021/jm00392a006

Reference yield:

: 4053-44-5
5-(hydroxymethyl)-8-hydroxyquinoline

: 128232-11-1
5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 55 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h

4: 1.98 g / Ac₂O / 2.5 h / 50 °C

5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

6: 35 percent / butan-1-ol / 24 h / Heating

7: H₂ / 5percent Pd/C / methanol / 5 h / 2585.7 Torr

With hydrogen; acetic anhydride; sodium hydride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium on activated charcoal; In methanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm00392a006

Reference yield:

: 66546-38-1
8-(benzyloxy)carbostyril-5-carboxaldehyde

: 128232-11-1
5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

2: 35 percent / butan-1-ol / 24 h / Heating

3: H₂ / 5percent Pd/C / methanol / 5 h / 2585.7 Torr

With hydrogen; sodium hydride; dimethyl sulfoxide; palladium on activated charcoal; In methanol; butan-1-ol;
DOI:10.1021/jm00392a006