8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

Base Information

Chemical Name:8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one
CAS No.:128232-09-7
Molecular Formula:C₂₈H₂₉IN₂O₃
Molecular Weight:568.454
Hs Code.:

Synonyms:8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

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Chemical Property of 8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

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Technology Process of 8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

There total 10 articles about 8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 96684-29-6
2-amino-2-methyl-1-(4-iodophenyl)propane

: 112281-28-4
8-benzyloxy-5-(epoxyethyl)-(1H)-quinolin-2-one

: 128232-09-7
8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

Guidance literature:: In butan-1-ol; for 24h; Heating;
DOI:10.1021/jm00392a006

Reference yield:

: 4053-44-5
5-(hydroxymethyl)-8-hydroxyquinoline

: 128232-09-7
8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 55 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h

4: 1.98 g / Ac₂O / 2.5 h / 50 °C

5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

6: 35 percent / butan-1-ol / 24 h / Heating

With acetic anhydride; sodium hydride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane; butan-1-ol;
DOI:10.1021/jm00392a006

Reference yield:

: 66546-38-1
8-(benzyloxy)carbostyril-5-carboxaldehyde

: 128232-09-7
8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

2: 35 percent / butan-1-ol / 24 h / Heating

With sodium hydride; dimethyl sulfoxide; In butan-1-ol;
DOI:10.1021/jm00392a006