ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate

Base Information

Chemical Name:ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate
CAS No.:1219366-63-8
Molecular Formula:C₂₃H₂₇F₃N₂O₃S
Molecular Weight:468.54
Hs Code.:

Synonyms:ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate

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Chemical Property of ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate

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Technology Process of ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate

There total 3 articles about ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.2%

: 421-53-4
2,2,2-trifluoro-1,1-ethanediol

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1219366-63-8
ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate

Guidance literature:: 2,2,2-trifluoro-1,1-ethanediol; (S)-2-methylpropane-2-sulfinamide; In toluene; at 40 ℃; for 4h; Molecular sieve;

ethyl N-diphenylmethylene glycine; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;

Reference yield: 17.0%

: 929642-48-8,1219607-83-6
(S,E)-2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 1219366-63-8
ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate

Guidance literature:: ethyl N-diphenylmethylene glycine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

(S,E)-2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide; In tetrahydrofuran; toluene; at -78 ℃; diastereoselective reaction;
DOI:10.1021/acs.jmedchem.7b00377

Reference yield:

: 1219607-83-6
(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 1219366-63-8
ethyl (2S,3R)-3-(((S)-tert-butyl(hydroxy)-4-sulfanyl)amino)-2-((diphenylmethylene)amino)-4,4,4-trifluorobutanoate

Guidance literature:: ethyl N-diphenylmethylene glycine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide; In tetrahydrofuran; toluene; at -78 ℃;