Gfnanzimvaiwhm-mgvprkgpsa-

Base Information Edit

Chemical Name:Gfnanzimvaiwhm-mgvprkgpsa-
CAS No.:124-94-7
Molecular Formula:C21H27FO6
Molecular Weight:394.44
Hs Code.:2937220000
NSC Number:757365
ChEMBL ID:CHEMBL3039453
Mol file:124-94-7.mol

Synonyms:Spectrum_000302;Spectrum2_000949;Spectrum3_001367;Spectrum4_000363;Spectrum5_001192;BSPBio_002894;KBioGR_000825;KBioSS_000782;DivK1c_000340;SPECTRUM1500586;SPBio_000918;CHEMBL3039453;SCHEMBL13046620;GFNANZIMVAIWHM-MGVPRKGPSA-;HMS501A22;KBio1_000340;KBio2_000782;KBio2_003350;KBio2_005918;KBio3_002114;NINDS_000340;HMS1921G07;HMS2092O11;Pharmakon1600-01500586;CCG-39675;NSC757365;NSC-757365;IDI1_000340;NCGC00178404-01;SBI-0051541.P002;T2303;AB00052113_02;SR-05000002080;SR-05000002080-1;BRD-A37780065-001-01-1;BRD-A37780065-001-03-7;(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl;InChI=1/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13?,14?,15-,16+,18+,19+,20+,21+/m1/s1

Suppliers and Price of Gfnanzimvaiwhm-mgvprkgpsa-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Triamcinolone
250mg
$ 322.00

TRC
Triamcinolone
250mg
$ 55.00

TRC
Triamcinolone
1g
$ 120.00

Sigma-Aldrich
Triamcinolone
250mg
$ 83.70

Sigma-Aldrich
Triamcinolone
250mg
$ 80.70

Sigma-Aldrich
Triamcinolone
50mg
$ 28.90

Sigma-Aldrich
Triamcinolone British Pharmacopoeia (BP) Reference Standard
bp338
$ 183.00

Sigma-Aldrich
Triamcinolone United States Pharmacopeia (USP) Reference Standard
250mg
$ 366.00

Sigma-Aldrich
Triamcinolone
1g
$ 240.00

Sigma-Aldrich
Triamcinolone European Pharmacopoeia (EP) Reference Standard
$ 190.00

Total 168 raw suppliers

Chemical Property of Gfnanzimvaiwhm-mgvprkgpsa- Edit

Chemical Property:

Vapor Pressure:3E-16mmHg at 25°C
Melting Point:262-263 °C(lit.)
Refractive Index:1.617
Boiling Point:587.5 °C at 760 mmHg
PKA:11.57±0.70(Predicted)
Flash Point:309.1 °C
PSA：115.06000
Density:1.42 g/cm³
LogP:0.62050
Storage Temp.:Refrigerator
Solubility.:DMF: soluble20 mg/mL
Water Solubility.:79.99mg/L(25 oC)
XLogP3:1.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:394.17916674
Heavy Atom Count:28
Complexity:807

Purity/Quality:

99% ^*data from raw suppliers

Triamcinolone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 40
Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC43C)F)O
Isomeric SMILES:C[C@]12C[C@@H]([C@]3(C(C1C[C@H]([C@@]2(C(=O)CO)O)O)CCC4=CC(=O)C=C[C@@]43C)F)O
Description A natural extension of corticoid research involved examination of compounds containing both a 9α-fluoro group and a double bond between positions 1 and 2. Triamcinolone (9-fluoro-11β, 16α, 17, 21-tetrahydroxypregna- 1,4-diene-3,20-dione), introduced in 1958, combines the structural features of a ?1 -corticoid and a 9α-fluoro corticoid. As mentioned previously, the 9α-fluoro group increases the anti-inflammatory potency, but it also markedly increases the mineralocorticoid potency. This is undesirable if the drug is to be used internally for the treatment of rheumatoid arthritis. By inserting a 16α-hydroxy group into the molecule, one can decrease the mineralocorticoid activity.
Uses A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). Triamcinolone is a glucocorticoid. Triamcinolone is used as an antiasthmatic (inhalant); antiallergic (nasal).
Indications Intralesional bleomycin, a cytotoxic drug that inhibits DNA synthesis, is effective for all varieties of recalcitrant warts. Various concentrations of the drug have been used, although the total dose must be carefully tracked over time to avoid potential systemic toxicity.
Therapeutic Function Glucocorticoid
Clinical Use Triamcinolone to be used topically is generally dispensed as its more potent and lipophilic acetonide, a 16α,17α-methylenedioxy cyclic ketal or isopropylidene derivative. It is effective in the treatment of psoriasis and other corticoid-sensitive dermatologic conditions. Topically, triamcinolone acetonide is a more potent derivative of triamcinolone and is approximately eight times more active than prednisolone.
Drug interactions Potentially hazardous interactions with other drugs Aldesleukin: avoid concomitant use. Antibacterials: metabolism accelerated by rifamycins; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced. Anticoagulants: efficacy of coumarins and phenindione may be altered. Antiepileptics: metabolism accelerated by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone. Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole. Antivirals: concentration possibly increased by ritonavir. Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids. Cobicistat: concentration of triamcinolone possibly increased. Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics. Vaccines: high dose corticosteroids can impair immune response to vaccines; avoid with live vaccines.

Technology Process of Gfnanzimvaiwhm-mgvprkgpsa-

There total 34 articles about Gfnanzimvaiwhm-mgvprkgpsa- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.29%