4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester
• CAS No.: 1026681-17-3
• Molecular Formula: C₂₂H₂₃NO₄
• Molecular Weight: 365.429

Synonyms:4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property of 4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester

There total 5 articles about 4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-benzoyl)-4-nitro-butyric acid ethyl ester (1027205-08-8) → 4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester (1026681-17-3)

Guidance literature:

With hydrogen; W-2 Raney Ni; In ethyl acetate; under 3040 Torr;

DOI:10.1021/jm960077r

Reference yield:

2.3-dihydrobenzofuran (496-16-2) → 4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester (1026681-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) SnCl₄, 2.) 50percent aq. NaOH / 1.) CH₂Cl₂, 2.) 15 deg C

2: DBU / propan-2-ol; tetrahydrofuran

3: H₂ / W-2 Raney Ni / ethyl acetate / 3040 Torr

With sodium hydroxide; hydrogen; tin(IV) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; W-2 Raney Ni; In tetrahydrofuran; ethyl acetate; isopropyl alcohol;

DOI:10.1021/jm960077r

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 4-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester (1026681-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH

2: DBU / propan-2-ol; tetrahydrofuran

3: H₂ / W-2 Raney Ni / ethyl acetate / 3040 Torr

With hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; W-2 Raney Ni; In tetrahydrofuran; ethyl acetate; isopropyl alcohol;

DOI:10.1021/jm960077r

upstream raw materials:

3-(2,3-Dihydro-benzofuran-5-yl)-2-(4-methoxy-benzoyl)-4-nitro-butyric acid ethyl ester

2.3-dihydrobenzofuran

1-(4-methoxyphenyl)ethanone

ethyl 4-methoxybenzoylacetate

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