6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide

Base Information

Chemical Name:6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide
CAS No.:1403495-72-6
Molecular Formula:C₁₅H₁₄FNO₄S
Molecular Weight:323.345
Hs Code.:

Synonyms:6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide

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Chemical Property of 6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide

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Technology Process of 6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide

There total 3 articles about 6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1403495-70-4
C₁₃H₉FO₄S

: 141-43-5
ethanolamine

: 1403495-72-6
6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide

Guidance literature:: C₁₃H₉FO₄S; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.25h;

ethanolamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1016/j.bmcl.2012.07.098

Reference yield:

: 80967-34-6
1-(4-fluorophenyl)-3,3-bis(methylthio)prop-2-en-1-one

: 1403495-72-6
6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1,4-dioxane / 6 h / 0 - 70 °C

2.1: water

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h

3.2: 5 h / 20 °C

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.098

Reference yield:

: 6-(4-Fluoro-phenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carboxylic acid ethyl ester

: 1403495-72-6
6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h

2.2: 5 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.098