Technology Process of 4-allyl-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-2,3,6-trimethoxytoluene
There total 13 articles about 4-allyl-5-<2-(methoxycarbonyl)-1-pyrrolidinyl>-2,3,6-trimethoxytoluene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
barium dihydroxide;
In
N,N-dimethyl-formamide;
for 5h;
DOI:10.1021/jo00133a034
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min
2: 1.) 1 M aq. Na2S2O4 (pH 7.0), 2.) Na2S2O4 / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min
3: K2CO3 / various solvent(s) / 1.5 h / Heating
4: various solvent(s) / 41 h
5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature
6: 96 percent / H2 / 5percent Pd/C / methanol / 42 h / 2585.7 Torr
7: 100 percent / K2CO3 / dimethylformamide / 10.5 h
8: 61 percent / various solvent(s) / 2.5 h / Heating
9: 88 percent / anhydrous barium hydroxide / dimethylformamide / 5 h
With
barium dihydroxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a034
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) copper acetate monohydrate, oxygen / 1.) methanol, room temp., 10 min
2: 1.) 1 M aq. Na2S2O4 (pH 7.0), 2.) Na2S2O4 / 1.) 3-pentanone, 15 min, 2.) reflux, 105 min
3: K2CO3 / various solvent(s) / 1.5 h / Heating
4: various solvent(s) / 41 h
5: 83 percent / barium hydroxide octahydrate / dimethylformamide / 32 h / Ambient temperature
6: 96 percent / H2 / 5percent Pd/C / methanol / 42 h / 2585.7 Torr
7: 100 percent / K2CO3 / dimethylformamide / 10.5 h
8: 61 percent / various solvent(s) / 2.5 h / Heating
9: 88 percent / anhydrous barium hydroxide / dimethylformamide / 5 h
With
barium dihydroxide; sodium dithionite; barium hydroxide octahydrate; hydrogen; oxygen; copper (I) acetate; potassium carbonate;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a034
