[2S-(2α(1R,2S),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester
CAS No.:866456-89-5
Molecular Formula:C₃₂H₄₂O₅
Molecular Weight:506.682
Hs Code.:

Synonyms:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

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Chemical Property of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

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Technology Process of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

There total 3 articles about [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 824952-29-6
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethanol

: 5292-43-3
bromoacetic acid tert-butyl ester

: 866456-89-5
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; Heating;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 579-43-1
(1S,2R)-1,2-diphenylethane-1,2-diol

: 866456-89-5
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / p-toluenesulfonic acid; triphenylphosphine hydrobromide / CH₂Cl₂ / 20 °C

2: 98 percent / NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

With triphenylphosphine hydrobromide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 108031-80-7
(2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran]

: 866456-89-5
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / p-toluenesulfonic acid; triphenylphosphine hydrobromide / CH₂Cl₂ / 20 °C

2: 98 percent / NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

With triphenylphosphine hydrobromide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/j.tetasy.2005.06.033