[2S-(2α(1R,2S),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester
CAS No.:866456-91-9
Molecular Formula:C₃₃H₄₄O₅
Molecular Weight:520.709
Hs Code.:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

Synonyms:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

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Chemical Property of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

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Technology Process of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

There total 5 articles about [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 866456-89-5
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

: 74-88-4
methyl iodide

: 866456-91-9
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

Guidance literature:: [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -15 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at -15 - 20 ℃;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 824952-29-6
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethanol

: 866456-91-9
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

2.1: LDA / tetrahydrofuran / 0.33 h / -15 °C

2.2: 92 percent / tetrahydrofuran / -15 - 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 866456-91-9
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

2.1: LDA / tetrahydrofuran / 0.33 h / -15 °C

2.2: 92 percent / tetrahydrofuran / -15 - 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/j.tetasy.2005.06.033