(4-(benzo[d]oxazol-2-yl)phenyl)boronic acid

Base Information

• Chemical Name: (4-(benzo[d]oxazol-2-yl)phenyl)boronic acid
• CAS No.: 1065657-51-3
• Molecular Formula: C₁₃H₁₀BNO₃
• Molecular Weight: 239.038
• Mol file: 1065657-51-3.mol

Synonyms:(4-(benzo[d]oxazol-2-yl)phenyl)boronic acid

Chemical Property of (4-(benzo[d]oxazol-2-yl)phenyl)boronic acid

Chemical Property:

• Boiling Point: 416.8±47.0 °C(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(benzo[d]oxazol-2-yl)phenyl)boronic acid

There total 4 articles about (4-(benzo[d]oxazol-2-yl)phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

2-(4-bromophenyl)-1,3-benzoxazole (3164-13-4) + Trimethyl borate (121-43-7,63156-11-6) → (4-(benzo[d]oxazol-2-yl)phenyl)boronic acid (1065657-51-3)

Guidance literature:

2-(4-bromophenyl)-1,3-benzoxazole; With n-butyllithium; In tetrahydrofuran; at -95 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; for 2.5h; Inert atmosphere;

Reference yield:

2-amino-phenol (95-55-6) → (4-(benzo[d]oxazol-2-yl)phenyl)boronic acid (1065657-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 4 h / Inert atmosphere; Reflux

3.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.2: 16 h / -78 - 20 °C

3.3: 1 h

With n-butyllithium; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; toluene;

Reference yield:

4-chlorobenzoyl chloride (586-75-4) → (4-(benzo[d]oxazol-2-yl)phenyl)boronic acid (1065657-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 4 h / Inert atmosphere; Reflux

3.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.2: 16 h / -78 - 20 °C

3.3: 1 h

With n-butyllithium; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; toluene;

upstream raw materials:

2-(4-bromophenyl)-1,3-benzoxazole

Trimethyl borate

4-chlorobenzoyl chloride

2-amino-phenol

Downstream raw materials:

2-[4-(10-phenyl-9-anthryl)phenyl]benzoxazole

Refernces

• 1、 -. "Novel host light-emitting material as well as synthetic method and application thereof". Paragraph 0046; 0050; 0051. . Retrieved 2018/11/27.
• 2、 -. "Organic Compound, Benzoxazole Derivative, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using Benzoxazole Derivative". Page/Page column 60. . Retrieved 2012/07/27.