Technology Process of cis-3,4-epoxy-1-(4-methoxyphenyl)quinolizidine
There total 4 articles about cis-3,4-epoxy-1-(4-methoxyphenyl)quinolizidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; trifluoroacetic anhydride;
In
dichloromethane;
1.) 0 deg C, 3 h, 2.) trifluoroacetic acid, 23 deg C, 3 h, then 0 deg C, 8 h;
DOI:10.1021/jo00174a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 30 percent / sodium hydroxide / ethanol; H2O / 1.5 h / 4 °C
2: 94 percent / benzene / 2 h / Heating
3: 2.3M BuLi / hexane; diethyl ether / 2 h / 0 °C
4: 76 percent / 1.) trifluoroacetic anhydride, 50percent aq. H2O2 / CH2Cl2 / 1.) 0 deg C, 3 h, 2.) trifluoroacetic acid, 23 deg C, 3 h, then 0 deg C, 8 h
With
sodium hydroxide; n-butyllithium; dihydrogen peroxide; trifluoroacetic anhydride;
In
diethyl ether; ethanol; hexane; dichloromethane; water; benzene;
DOI:10.1021/jo00174a009
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 94 percent / benzene / 2 h / Heating
2: 2.3M BuLi / hexane; diethyl ether / 2 h / 0 °C
3: 76 percent / 1.) trifluoroacetic anhydride, 50percent aq. H2O2 / CH2Cl2 / 1.) 0 deg C, 3 h, 2.) trifluoroacetic acid, 23 deg C, 3 h, then 0 deg C, 8 h
With
n-butyllithium; dihydrogen peroxide; trifluoroacetic anhydride;
In
diethyl ether; hexane; dichloromethane; benzene;
DOI:10.1021/jo00174a009
