4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

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Chemical Name:4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid
CAS No.:1352835-81-4
Molecular Formula:C₂₉H₂₄FN₃O₆
Molecular Weight:529.524
Hs Code.:

Synonyms:4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

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Chemical Property of 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

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Technology Process of 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

There total 10 articles about 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1352835-80-3
ethyl 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate

: 1352835-81-4
4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

Guidance literature:: ethyl 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; for 1.5h;

With hydrogenchloride; In water; pH=4 - 5;

Reference yield:

: 2380-86-1
6-hydroxy-1H-indole

: 1352835-81-4
4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

2.1: 125 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere

3.2: pH ~ 11

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

4.2: pH 10

4.3: 3.5 h / 125 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h

5.2: pH 4 - 5

With hydrogenchloride; lithium hydroxide monohydrate; water; ammonium chloride; caesium carbonate; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1352835-81-4
4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / tetrahydrofuran / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C / Inert atmosphere

2.2: 1.33 h / Cooling with ice

3.1: acetic acid / 2 h / 90 °C / Inert atmosphere

4.1: 125 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere

5.2: pH ~ 11

6.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

6.2: pH 10

6.3: 3.5 h / 125 °C

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h

7.2: pH 4 - 5

With hydrogenchloride; lithium hydroxide monohydrate; water; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;