Technology Process of ethyl 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate
There total 9 articles about ethyl 4-(3-(benzyloxycarbonylamino)-2-fluorophenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
glyoxylic acid ethyl ester; benzyl 3-(2-amino-1-(6-(2-methoxyethoxy)-1H-indol-3-yl)ethyl)-2-fluorophenylcarbamate;
With
hydrogenchloride;
In
1,4-dioxane; toluene;
at 20 ℃;
for 16h;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
pH=10;
palladium 10% on activated carbon;
In
para-xylene;
at 125 ℃;
for 3.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C
2.1: 125 °C
3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere
3.2: pH ~ 11
4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C
4.2: pH 10
4.3: 3.5 h / 125 °C
With
hydrogenchloride; ammonium chloride; caesium carbonate; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / tetrahydrofuran / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C / Inert atmosphere
2.2: 1.33 h / Cooling with ice
3.1: acetic acid / 2 h / 90 °C / Inert atmosphere
4.1: 125 °C
5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / Inert atmosphere
5.2: pH ~ 11
6.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C
6.2: pH 10
6.3: 3.5 h / 125 °C
With
hydrogenchloride; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
