tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate
CAS No.:1613289-45-4
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1613289-26-1
4-chloro-6-phenylpyridin-2(1H)-one

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1613289-45-4
tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate

Guidance literature:: 4-chloro-6-phenylpyridin-2(1H)-one; 1-(tert-butoxycarbonyl)-4-aminopiperidine; With caesium carbonate; In toluene; for 0.166667h; Inert atmosphere;

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; at 120 ℃; for 0.75h; Microwave irradiation;
DOI:10.1021/jm5005978

Reference yield:

: 98-80-6
phenylboronic acid

: 1613289-45-4
tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

2.1: sodium nitrite; sulfuric acid / water / 3.5 h / 0 °C

3.1: caesium carbonate / toluene / 0.17 h / Inert atmosphere

3.2: 0.75 h / 120 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; caesium carbonate; sodium nitrite; In 1,2-dimethoxyethane; water; toluene; 1.1: |Suzuki Coupling;
DOI:10.1021/jm5005978

Reference yield:

: 116632-24-7
2-amino-4,6-dichloropyridine

: 1613289-45-4
tert-butyl 4-(2-oxo-6-phenyl-1,2-dihydropyridin-4-ylamino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

2.1: sodium nitrite; sulfuric acid / water / 3.5 h / 0 °C

3.1: caesium carbonate / toluene / 0.17 h / Inert atmosphere

3.2: 0.75 h / 120 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; caesium carbonate; sodium nitrite; In 1,2-dimethoxyethane; water; toluene; 1.1: |Suzuki Coupling;
DOI:10.1021/jm5005978